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For the most part, all the benefits of synthetic engine oils do apply to higher mileage car engines.

If, however, the old high mileage engine is very worn (and I mean worn well beyond acceptable limits for normal operation) of if ignition or fuel system malfunctions exist resulting in contamination of the oil, then any "extended drain" benefits from synthetic oil do not apply. In such case it may be more sensible to use the least expensive oil available which meets the engine manufacturer's specifications.

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