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Many things can cause such an issue, but the one issue that is solely S-10 related is that the earlier-model poppet-style fuel injectors used in the '96-and-up model year Vortec engines were prone to sticking open or sticking shut after a large mileage buildup. Gm was even forced to address the issue in the early '00's by updating the injector style. The new injectors had the same flow rate, but were designed in such a way as to alleviate the problems found in the earlier ones. There was even a forced recall/replacement in the state of CA due to a lawsuit by the EPA in that state, claiming the poor design was leading to a higher-than-average rate of emissions testing failures in the above-described model years. This is oftentimes the culprit in the 4.3 engines when all the other standard solutions have been exhausted, ie: spark plugs, wires, cap and rotor, etc...

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