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446 miles taking this route:

  1. Take the TURNPIKE (toll) NORTH from Orlando to I-75 NORTH.
  2. Take I-75 NORTH to I-10 to JACKSONVILLE and TALLAHASSEE at EXIT 435 near Lake City. Follow signs on the exit ramp to I-10 WEST to TALLAHASSEE.
  3. Take I-10 WEST to Pensacola. To get to downtown or the beaches, take I-110 SOUTH (EXIT 12 off I-10).
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