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From Broad St in Charleston to the middle of Florence, SC. is a 136 mile trip if you take I-26W out of Charleston and connect with I-95N just up the road. It'll take 2hrs 4min depeinding on traffic or holiday conditions. However if you want less milage (113-123miles) and a slightly slower trip, try the 2.5 hour scenic trip. You can either take US 52W and then 52N or take SC 41N all the way and they will both get you safely into Florence.

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