It is 298.14 miles according to MapQuest.
The Keys are 120 miles long. Fort Myers to Key West is 302 miles.
Sanibel Island is about 25 Km west opf South West Florida International at Ft. Myers.
299 miles taking this route:Take I-75 SOUTH from Ft. Myers to Florida's TURNPIKE (toll) SOUTH to KEY WEST at EXIT 5, outside of Miami.Take Florida's Turnpike (toll) SOUTH to U.S. 1 SOUTH to KEY WEST at END Florida's Turnpike in HOMESTEAD.Take U.S. 1 SOUTH to Key West.
It is 125 miles according to Google Maps.
It is 126 miles according to Google Maps.
About 130 miles
299 miles taking this route:Take I-75 SOUTH from Ft. Meyers to Florida's TURNPIKE (toll) SOUTH to KEY WEST off EXIT 5.Take the TURNPIKE (toll) SOUTH to U.S. 1 SOUTH to KEY WEST in Homestead.Take U.S. 1 SOUTH to Key West.
192 miles taking this route:Take I-4 WEST from Orlando to I-75 to OCALA and NAPLES at EXIT 9 in Tampa. Follow signs to I-75 SOUTH to NAPLES.Take I-75 SOUTH to Ft. Myers.
The straight line distance is http://wiki.answers.com/q8570897.htmlto 125 nautical miles.
1264 miles
Ft. Lauderdale is farther from Key West then Miami. Therefore it is easier to drive from Miami to Key West.