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415 miles taking this route:

  1. Take I-95 SOUTH, from Daytona Beach, to SR-70 OKEECHOBEE RD at EXIT 129; turn right off the exit ramp onto SR-70 WEST.
  2. Take SR-70 WEST (breifly) to Florida's TURNPIKE; turn left onto the on-ramp, and then, once you are past the toll booth, follow signs to the TURNPIKE - SOUTH to MIAMI.
  3. Take the TURNPIKE (toll) SOUTH to U.S. 1 SOUTH to KEY WEST at END Florida's TURNPIKE in Homestead.
  4. Take U.S. 1 SOUTH to Key West.
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