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875 miles taking this route:

  1. Take I-66 WEST (towards FRONT ROYAL), from Washington, D.C., to I-81 SOUTH to ROANOKE off EXIT 1A.
  2. Take I-81 SOUTH to I-64 WEST to CHARLESTON off EXIT 191, near Lexington.
  3. Take I-64 WEST to St. Louis.
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