How far is Williamsport PA from Pittsburgh PA?

Answer 1

It is around 250 miles.

The route:

1. Take U.S. 220 SOUTH to I-80 WEST.
2. Take I-80 WEST to I-79 SOUTH to PITTSBURGH at EXIT 19A.
3. Take I-79 SOUTH to Pittsburgh. To get to downtown, take I-376 EAST at EXIT 59A and then go into downtown via the FORT PITT TUNNEL.