The driving distance between Naples, FL and Destin, FL is approximately 600 miles. The driving time would be approximately 9 hours 45 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work and rush hour traffic in urban areas.)
47 miles
133
452 miles
It is 433.79 miles according to MapQuest.
Atlanta, GA to Destin, FL is 315 road miles.
It is 416 miles according to Google Maps.
It is 485 miles according to Google Maps.
It is 26.1 miles according to Google Maps.
452 miles
320 miles
According to Bing Maps, it is 115.1 miles from Naples, FL to Miami, FL.
about 101 miles up I-75.