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Driving fromTwentynine Palms, CA to Las Vegas, NV is between 189 miles to 220 miles depending on the route that is driven. If you stick to the interstate you are looking at 220 miles.However, if you follow the "back" roads that take you through the Mojave National Preserve, Kelso, Cima and finally Interstate 15, you are looking at 189 miles with a drive time of approximately 3 hours when following the posted speed limits through the preserve.

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16y ago

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