5 and 1/2 to 6 hours
Whether you should drive or take a boat from Ft. Myers to Key West depends on how much time you have, what the weather along the route will be, the relative costs (boat is likely to be more costly), and whether you are more board by a long drive or an extended boat ride.
The Keys are 120 miles long. Fort Myers to Key West is 302 miles.
28hrs.
14 weeks
5 seconds
It is 160.34 miles according to MapQuest.
300 miles.
The total driving distance from Fort Myers, FL to Key West, FL is 302 miles.Take I-75 SOUTH (towards NAPLES) from Ft Myers to Florida's TURNPIKE (toll) - SOUTH to KEY WEST at EXIT 5. Please note that I-75 thru the Everglades (past Naples) is ALLIGATOR ALLEY, which is a toll road.Take the TURNPIKE (toll) - SOUTH to U.S. 1 SOUTH to HOMESTEAD (and KEY WEST) at the END of the Turnpike in Homestead.Take U.S. 1 SOUTH to Key West.
Ft. Lauderdale is farther from Key West then Miami. Therefore it is easier to drive from Miami to Key West.
4 1/2 hours
Map quest it.