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The driving distance between Charleston, SC and Charlotte, NC is approximately 210 miles. The driving time would be approximately 3 hours 30 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)
If you take I-77 S and I-26 E, it will take about 3 hours and 41 minutes. If you take just I-26 E, it will take about 3 hours and 59 minutes. If you take US 521 S it will take 4 hours and 5 minutes.

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14y ago

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