The driving distance between Detroit, MI and Louisville, KY is approximately 360 miles. The driving time would be approximately 5 hours 45 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)
It is 361 miles and an estimated driving time of 6 hours and 1 minute according to Google Maps.
30 hours
4 hours
65mph the drive =4 hours 75-80mph the drive =3 hours
21
20mins
11 and 1/2 to 12 hours
Google Maps estimates the driving time as 27 hours.
8 to 10 hours + stops
Four and a half
11 and 1/2 hours
Google Maps estimates the driving time as 11 hours.