How many miles between Poughkeepsie and Buffalo?

Answer 1

355 miles taking this route:

1. Take NY-55 WEST from Poughkeepsie to U.S. 9W NORTH across the river in Highland. Continue on U.S. 9W NORTH to NY-299. Turn left onto NY-299 WEST, then take NY-299 WEST to I-87 New York State THRUWAY (toll). Once you are past the toll booth, follow signs to I-87 NORTH.
2. Take the THRUWAY (toll) NORTH on I-87 to Albany, then WEST on I-90 past Albany, to Buffalo.