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573 miles taking this route:

  1. Take I-81 SOUTH from Lexington to I-77 SOUTH to CHARLOTTE, NC at EXIT 81.
  2. Take I-77 SOUTH to I-26 EAST to CHARLESTON (TO I-95) at END I-26 in COLUMBIA, South Carolina.
  3. Take I-26 EAST to I-95 SOUTH to SAVANNAH at EXIT 169A.
  4. Take I-95 SOUTH to U.S. 17 (SOUTH GEORGIA PKWY) to BRUNSWICK and WAYCROSS at EXIT 29 in GEORGIA; turn left off the exit ramp onto U.S. 17 towards BRUNSWICK.
  5. Take U.S. 17 NORTH to SR-520 to JEKYLL ISLAND; turn right onto SR-520 to JEKYLL ISLAND.
  6. Take SR-520 to Jekyll Island.
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