How many miles from key west fl to Tampa fl?

Answer 1

425 miles taking this route:

1. Take U.S. 1 NORTH (Overseas Highway across the Keys), from Key West, to Florida's TURNPIKE (toll) - NORTH to ORLANDO, in Homestead.
2. Take the TURNPIKE (toll) - NORTH to I-75 NORTH to NAPLES off EXIT 39.
3. Take I-75 NORTH to Tampa.