It is 824.69 miles according to MapQuest.
There are about 154.050 miles between Sanford, FL and Ft Myers, FL.
The distance between Ft. Myers FL and Tampa FL is about 128 road miles.
About 160.
150 miles taking I-595 WEST to I-75 NORTH towards NAPLES, then I-75 NORTH to Ft. Myers.
50 miles
About 115 miles.
It is 155 miles according to Google Maps.
About 77 miles. It is 76.29 miles according to MapQuest.
It is 156.50 miles accrding to MapQuest.
It is 216 miles according to Google Maps.
It is 120 miles taking I-75 SOUTH.
about 1100 miles