I-75 North to Exit 141
80 East to 29 to 27 North
70 East to 713 to Route 1 North
the shortest air route is a great circle
The distance from Baltimore, MD to Myrtle Beach, SC is about 487.2 miles (according to the shortest route on Mapquest).
wormhole
who am I
It appears that the Shortest route I can find is from Jacksonville Beach, FL to San Diego, CA, at a distance of 2,109 miles according to Google Maps.
The shortest route between two points on the surface of a planet, when routes are limited to the planet's surface, is the arc of the great circle that connects the two points. The shortest route between two points anywhere, without regard to intervening matter or energy preventing the route from being followed, is always the line connecting the two points.
The driving distance from Delray Beach, FL to Naples, FL is approximately 140 miles and takes about 2.5 to 3 hours depending on traffic and route taken.
Great Circle Route
Shortest route is 18 hours 59 minutes long
To get from Vero Beach, FL, to Naples, FL, the best route is to take I-95 South to I-595 West, then merge onto I-75 South (Alligator Alley). Stay on I-75 South until you reach the Naples exit. This route is approximately 120 miles and typically takes about 2 hours, depending on traffic conditions.
The route with the shortest driving time is about 115 miles.
The route with the shortest driving time is about 19 miles.