464 miles. I-70 West to I-57 South to I-55 South
Ohio
Take I-70 WEST from Indianapolis to I-57 SOUTH to MEMPHIS in Effingham, ILLINOIS.Take I-57 SOUTH to I-55 SOUTH to MEMPHIS at EXIT 1A in MISSOURI.Take I-55 SOUTH to I-12 WEST to BATON ROUGE at EXIT 29B in LOUISIANA.Take I-12 WEST to I-10 WEST in Baton Rouge.Take I-10 WEST to Houston.
The shortest distance is via route US-72 E. The shortest time is via route I-40 E and I-24 E.
In the shortest route the two largest would be Memphis and Nashville.
Through Houston, Texarkana, Memphis, Nashville and Louisville.
Shortest route 9 hours 7 mins. Longest route 10 hours 8 mins.
Take I-65 SOUTH to Nashville bypassing Indianapolis via I-465 SOUTH.
The city on the Atlantic seaboard that is the shortest distance from Indianapolis is likely Charleston, South Carolina. It is approximately 600 miles away from Indianapolis, making it one of the closest coastal cities along the Atlantic coast. Other nearby options include Savannah, Georgia, and Norfolk, Virginia, but Charleston is the most direct route.
It is 821 miles of road driving distance via the shortest route according to Google Mapws.
The shortest route is on I-90 W.
Depending on the route, the drive should take between 9 hours to 9 hours and 30 minutes.
The shortest route is I-75 N.