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The best driving route from Gainesville to Key West typically involves taking I-75 South toward Naples, then merging onto US-41 East (Tamiami Trail) to reach US-1 South, which leads directly to The Florida Keys. This scenic drive offers beautiful views, especially as you approach the Keys. Along the way, consider stopping at attractions like the Everglades National Park or various islands for a break. The total drive is about 7-8 hours, so plan for ample time to enjoy the journey.

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1w ago

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