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  1. Take I-64 WEST to I-81 SOUTH. Continue on I-81 SOUTH.
  2. Take I-81 SOUTH through Virginia to I-40 WEST towards KNOXVILLE at EXIT 1B in Tennessee.
  3. Take I-40 WEST to I-240 WEST towards JACKSON, MISS. at EXIT 10A outside of Memphis. On this stretch, bypass Knoxville by taking I-640 WEST (EXIT 393) and also bypass Nashville by taking I-440 WEST (EXIT 213A).
  4. Take I-240 around Memphis to I-55 SOUTH towards JACKSON, MISS at EXIT 25A.
  5. Take I-55 SOUTH into Mississippi to US-278 EAST towards OXFORD at EXIT 243-A.
  6. Take US-278 EAST to Oxford.
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