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The best driving route from Minnesota to South Carolina typically involves taking I-35 south to I-70 east, then connecting to I-75 south. This route allows for efficient travel through several major cities and offers rest stops and amenities along the way. Depending on your starting point in Minnesota and final destination in South Carolina, you may also consider alternative routes, but this is generally the most direct and straightforward option. Always check current traffic conditions and road closures before your trip.

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1mo ago

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