I-85 S to I-77 S to I-26 E to I-95 S
Greensboro, GA is approximately 320 miles northwest of Jacksonville, FL. The driving time is usually around 5-6 hours, depending on traffic and the route taken.
Greensboro, NC is about halfway but it can depend on the route you take
The fastest route to drive from Orlando Florida to Jacksonville Florida is on a US Interstate highway. In this case that highway is Rt. 95.
I-85 South through Durham, Greensboro, and Charlotte.
its about 257 miles depending on the route you take!
I-10 all the way
Longest route is 1,200 miles
On the route suggested by Google maps half way is Greensboro
oakville ontario to daytona
jacksineville
I-95 south to Jacksonville I-75 south to Tampa
The halfway point between Jacksonville, Florida and Sandusky, Ohio is Estatoe, North Carolina (depending on your exact route of course.