What is the distance between Naples FL and Amelia Island FL?

Answer 1

427 miles taking this route:

1. Take I-75 NORTH from Naples all the way up to I-10 to JACKSONVILLE and TALLAHASSEE at EXIT 435 near Lake City. Follow signs on the exit ramp to I-10 EAST to JACKSONVILLE.
2. Take I-10 EAST to I-95 NORTH to SAVANNAH via I-295 NORTH to bypass JACKSONVILLE (EXIT 356 off I-10 to get onto I-295, follow signs to I-295 NORTH to SAVANNAH ; EXIT 35B off I-295 to get onto I-95 NORTH to SAVANNAH).
3. Take I-95 NORTH to SR-200/A1A to CALLAHAN and FERNANDINA BEACH at EXIT 373 (12 miles north of I-295).
4. Turn right off the exit ramp and take SR-200/A1A NORTH to Amelia Island.