36 miles.
hahahahhahahahah
There are approximately 291.75 miles between Orlando, FL and Key Largo. The estimated driving time is 4 hours and 22 minutes.
thea awnser is 4 hours and twenty nine minutes
It is 296 miles according to Google Maps.
286.3 mi 4h15m +/-
check Mapquest.com
92 miles.
about 1560 miles
It is 145 miles from Key Largo to Marco Island via FL-90 N/US-41 N.
81 miles taking U.S. 1 (Overseas Highway).
Tampa to Key Largo is about 300 miles. Tampa to Key West is about 400 miles.