The short way - through Redding and Susanville- is just over 346 miles, taking about 7 hours with favorable traffic conditions.
But the FAST and EASY way is by taking the interstates all the way through (via Sacramento). This route is 417 miles and this is the route:
The driving distance from Colorado Springs, CO, USA to Eureka, CA, USA is 1444.18mi / 2324.19km
290 miles
The shortest driving distance is 316 miles. (509km).
The driving distance is about 275 miles on US-101.
291 miles
The driving distance from Orange County, CA, USA to Reno, NV, USA is 552.87mi / 889.77km
339 miles
The driving distance from Florence, OR 97439, USA to Eureka, CA, USA is 265mi / 426.6km
The shortest driving distance is 191 miles.
The driving distance from Redding to Eureka is 149 miles per Map Quest. The driving time per Map Quest is 3 hours and 8 minutes.
It is 414 miles according to Google Maps.
It is 275 miles via CA-88 and CA-49.