save your self a whole lot of gas and boredom.... Fly it for 240rt
I 95
According to Google Maps, the fastest route is 25 hours.
It is 600.08 miles when driving via Fort Worth and Wichita Falls which is the fastest route according to MapQuest.
Take I-10 WEST to Houston.
Fasted - depending on conditions - will be on I-95 S at just under 14 hours.
I-40 to US-287 and I-45 covers 884.55 miles in an estimated 13 hours and 45 minutes.
The distance between Tri-Cities and Spokane is approximately 150 miles, or about a two hour drive. The fastest route to take is US HWY 395 North which merges into I-90 East and wham bam! You's in Spokane!
1086 miles the fastest route
There's no "fastest way"
If you're driving (and take the fastest route) it would be St. Clairsville and Wheeling in Ohio and Washington in Pennsylvania. If the distance is direct it would be Parkersburg, West Virginia.
The fastest driving route from California to Virgina