What is the most direct driving route from Baltimore to new Orleans?

Answer 1

1. Take I-70 WEST to I-81 NORTH & SOUTH to HARRISBURG and ROANOKE at EXIT 26.
2. Exit at EXIT 26A onto I-81 SOUTH to ROANOKE. Take I-81 SOUTH through Maryland, West Virginia and Virginia to I-40 WEST to KNOXVILLE at EXIT 1B.
3. Take I-40 WEST to I-75 SOUTH. On this stretch, bypass Knoxville by taking I-640 WEST at EXIT 393.
4. Continue on I-75 SOUTH to I-24 WEST to CHATTANOOGA and BIRMINGHAM at EXIT 2.
5. Take I-24 WEST to I-59 SOUTH to BIRMINGHAM at EXIT 167.
6. Take I-59 SOUTH through Georgia, Alabama and Mississippi to I-10 WEST to New Orleans at EXIT 1C. On this stretch, bypass Birmingham by taking I-459 SOUTH (EXIT 137 off I-59).
7. Take I-10 WEST to New Orleans.