It depends if you want to go through the national park or not. I75 NB to Chatanooga, then cut over through Marysville to Gatlinburg.
Take I-10 WEST to I-75 SOUTH to TAMPA at EXIT 296A.Take I-75 SOUTH to Naples.
If you take a car, according to maps.google.com, the quickest route will be 286 miles and take approximately 4 hours and 21 minutes to drive.
305 miles taking this route: Take I-40 WEST, from Durham, to FOOTHILL PARKWAY to GATLINBURG at EXIT 443.Take FOOTHILL PARKWAY to U.S. 321 SOUTH to GATLINBURG.Take U.S. 321 SOUTH to Gatlinburg.
9 hours northern route and 10 hours southern route
The Gandy Bridge takes you directly from Tampa to St. Petersburg.
I-65 SOUTH (from INDIANA).
Take the Trans-Canada Highway EAST to Montreal.
I am travelling from Bangor Maine to Tampa Florida and I want to bypass New York Ciity. What route should I take?
Take I-95 SOUTH to I-4 WEST.Take I-4 WEST to Tampa.
Google Earth cites six or seven hours... depending on which route you take.
Take the turnpike north to Exit 193. Take 60 to 35 to 570 I-4 takes you into Tampa.
The distance between the start location and the destination is 647mi, (1,041km), and will take approximately 10 hours 23 minutes of driving time.