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There must be a supportive relationship with a health-care provider. One primary care provider should be all that a person with hypochondria has. Patients should not have their symptoms denied or challenged, but health care provider should tell the patient that they do not have disease. Health care provider should continue to follow-up with patient to help control symptoms.

Some antidepressants, selective serotonin re-uptake inhibitors (SSRIs) can help.

Psychotherapy can be helpful as can Cognitive Behavioral Therapy. These therapies should help to allow patient to recognize what seems to make the symptoms worse, to develop methods of coping with the symptoms, and trying to keep themselves active.

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