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If the cells are part of the same organism, then no, they don't contain different genes. This is a common misconception - although the two cells have very different functions, they have the exact same DNA. The difference is due to the way the DNA is transcribed and translated. Genes that function as enzymes in the liver will be present in the DNA of a kidney cell, but it won't be expressed into the polypeptide.

There are a variety of factors that may "turn off" a gene, some of which include histone acetylation and DNA methylation. If nucleosomes in a chromosome are not acetylated, then they will be more condensed into one area. This in turn may block the RNA polymerase from attaching to a promoter sequence and transcribing the gene. Similarly, methyl groups can bond to the gene, blocking RNA polymerase. This ensures that genes that usually function in different organs aren't expressed.

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Q: Do liver and kidney cells contain different genes?
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