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During the anaphase phase of meiosis, there can be non-dysjunction. This is when the spindle fibres do not effectively pull apart the chromosomes, leading to the cells having unequal numbers of chromosomes (ie. 3 and 1 rather than 2 and 2).

An example of this is Trisomy 21, which is when there is non-disjunction of the 21st chromosome in either Anaphase I or Anaphase II. This causes Down's syndrome.

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