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Not generally; you normally won't be able to tell visually that a person may have an STD.

In some cases, you might be able to recognize blisters similar to cold sores, which can be indicative of the Herpes virus, but not all herpes causes these blisters, and not all blisters are symptoms of herpes. Severe STDs may cause a visible rash or an odorous discharge, but again, these are not reliable indicators either way.

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