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Your question is ambiguous and could refer to any of the following:
- Prokaryotes employ proteins that recognise termination sites, including the 'tus' protein. These bind and act as one way gates, so that termination occurs in a predefined location. The exact mechanism of termination is unknown, but is presumed to be a simple meeting of two replication forks causing the apparatus to stop and dissociate. Replication is successful without the tus protein.
- In eukaryotes, termination of replication is poorly understood.
- Eukaryotes have linear DNA, and as such cannot replicate a short region on the end of each DNA molecule on the lagging strand, since replication requires RNA primers, and there will be nowhere for the primer to bind (it is later degraded so cannot be kept). Eukaryotes therefore use telomeress, which are GT rich repeating units that 'protect' the end of the DNA and can be placed without the use of a templace (the telomerase enzyme itself has an RNA template within it). The sequence of the telomere is species dependent. There will always be an overhang on the telomere, where telomerase added bases that could not be replicated on the other strand (as there is still nowhere to put the primer).
What else can I help you with?
What is the significance of the end replication problem in eukaryotes and how does it impact the overall process of DNA replication?
The end replication problem in eukaryotes refers to the challenge of replicating the ends of linear chromosomes, which leads to the loss of genetic material with each cell division. This impacts DNA replication by causing the gradual shortening of chromosomes over time, which can eventually lead to cell aging and potentially contribute to diseases like cancer.
True or false replication start at one end of DNA molecule and proceeds to the other end?
False: DNA replication starts at origins of replication which can be anywhere on the DNA molecule. Replication is taking place at multiple origins at the same time.
What is the significance of the end of DNA in the process of genetic replication?
The end of DNA is significant in genetic replication because it marks the completion of the replication process. This ensures that the new DNA strands are fully synthesized and identical to the original DNA, allowing for accurate transmission of genetic information to daughter cells.
What is the difference between the 5' and 3' end in DNA replication?
In DNA replication, the 5' end refers to the end of the DNA strand where the phosphate group is attached to the 5th carbon of the sugar molecule, while the 3' end refers to the end where the hydroxyl group is attached to the 3rd carbon of the sugar molecule. This difference in orientation is important for the directionality of DNA synthesis during replication.
What is the significance of the 3' end of DNA in the process of DNA replication?
The 3' end of DNA is important in DNA replication because it serves as the starting point for the addition of new nucleotides during the synthesis of a new DNA strand. The enzyme responsible for adding new nucleotides can only attach them to the 3' end of the existing DNA strand, so the presence of a free 3' end is crucial for the replication process to proceed smoothly.
What is the significance of the end replication problem in eukaryotes and how does it impact the overall process of DNA replication?
The end replication problem in eukaryotes refers to the challenge of replicating the ends of linear chromosomes, which leads to the loss of genetic material with each cell division. This impacts DNA replication by causing the gradual shortening of chromosomes over time, which can eventually lead to cell aging and potentially contribute to diseases like cancer.
What happens at the DNA replication fork?
The DNA replication fork is where the replication origin forms the Y shape. The replication fork moves down the DNA strand to the strand's end, resulting in every replication fork having a twin.
True or false replication start at one end of DNA molecule and proceeds to the other end?
False: DNA replication starts at origins of replication which can be anywhere on the DNA molecule. Replication is taking place at multiple origins at the same time.
At the end of DNA replication what are you left with?
Genital Warts
What is the significance of the end of DNA in the process of genetic replication?
The end of DNA is significant in genetic replication because it marks the completion of the replication process. This ensures that the new DNA strands are fully synthesized and identical to the original DNA, allowing for accurate transmission of genetic information to daughter cells.
What is the difference between the 5' and 3' end in DNA replication?
In DNA replication, the 5' end refers to the end of the DNA strand where the phosphate group is attached to the 5th carbon of the sugar molecule, while the 3' end refers to the end where the hydroxyl group is attached to the 3rd carbon of the sugar molecule. This difference in orientation is important for the directionality of DNA synthesis during replication.
What is the significance of the 3' end of DNA in the process of DNA replication?
The 3' end of DNA is important in DNA replication because it serves as the starting point for the addition of new nucleotides during the synthesis of a new DNA strand. The enzyme responsible for adding new nucleotides can only attach them to the 3' end of the existing DNA strand, so the presence of a free 3' end is crucial for the replication process to proceed smoothly.
What is an end replication problem?
The two strands of a DNA molecule are antiparallel to one another (the backbone of one strand runs from 5'-3' while the complimentary strand runs 3'-5'). Unfortunately, DNA polymerase, the enzyme responsible for replicating DNA, can only make DNA in a 5'-3' direction (and read DNA in the 3'-5' direction). Also, it needs a "primer" to give it a place to bind and start replication. So this creates a problem when synthesizing the 3'-5' stand because your enzyme will only synthesize 5'-3'. During replication this is solved by synthesizing small pieces of DNA ahead of the replication fork on the 5'-3' mother strand. Thus we have one daughter strand which is synthesized as a continuous piece of DNA (called the leading strand) and one daughter strand which is synthesized in small, discontinuous pieces (called the lagging strand). However, at the extreme end of the DNA, we run into another problem. The leading stand can be made to the very end, but the lagging strand cannot because you need the RNA primer upstream to begin each piece of the lagging strand DNA but at the end of the DNA there is nothing for this piece to attach to. Thus, the last section of the lagging strand cannot be synthesized and after several rounds of DNA replication, the DNA molecule gets smaller and smaller. This is "the end of replication problem" and it is solved by putting a DNA cap on the ends of DNA called a telomere which does not code for any protein, thus when this information is lost it does not have severe consequences for the cell.
Does replication of DNA begin at one end and process to the other?
Yes, absolutely; from the dsDna's five-prime [5'] end toward its three prime [3'] end.
What is the significance of the 3' end of a DNA strand in terms of genetic information processing and replication?
The 3' end of a DNA strand is important for genetic information processing and replication because it is where new nucleotides are added during DNA replication. This process is essential for copying the genetic information stored in the DNA molecule. The 3' end provides a site for the enzyme DNA polymerase to attach and add new nucleotides in the correct sequence, ensuring accurate replication of the DNA strand.
What is the job of the DNA polymerases?
DNA polymerase adds bases to the 3' end during replication. It matches the c with G and A with U during replication. Never add to the 5' end!
What is the direction of DNA replication in terms of the 5' to 3' orientation?
During DNA replication, the direction of synthesis is from the 5' to 3' end of the new strand.
