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in high altitude there is the same amount of O2 but there is an increase amount of atmospheric preassure, making it more difficult to acquire the same amount of O2 in every breath you take. so the body will start to hyperventilate.. creating a resp. alkalosis ( increase O2 and decrease Co2) that's why you feel lightheaded, and maybe numb or dizzy. so your body activates 2-3 BPG which is the one that regulates the movement of O2 between the RBC and the tissue. so the body will syntesize more 2-3BPG and increasing it causing the hb/O2 dissociation curve to shift to the right. which means the O2 will have more affinity to tissue.

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