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Yes. Especially if the infection spreads from the localized initial site and becomes a systemic disease. When this happens it is called septicemia, sepsis, SIRS, blood poisoning, etc. When the whole body is affected by the infection many systems can be seriously impacted, such as the kidneys, nervous system, heart, liver, etc. If these organs/systems fail, people can often die. Additionally, high fevers and dehydration from the infection can kill if the infection is not adequately treated in time. People have been known to die from infections that began as minor infections such as acne, dental infections, appendicitis, small cuts, puncture wounds, wounds from minor surgeries, wounds/ulcers (on the feet especially), burns, bronchitis, pneumonia, influenza, etc. When there are fever, redness, drainage, abscesses and other signs of infection, no matter how small, treatment should be initiated and if no improvement is seen within a few days or if the fever gets very high, seek a medical professional's exam.

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