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Bacillus Calmette-Guérin (sometimes Bacille Calmette-Guérin, or BCG) is a TB vaccine that is derived from a strain of weakened live bovine (cow) tuberculosis bacillus, Mycobacterium bovis. The vaccine sitmulates an immune response, and antibodies are generated as a result, just as is generally sought in the application of vaccines. The vaccine is fairly effective, but its effect is not protracted, and it has some odd geographic dependence. Wikipedia has more information, and you'll find a link to their post on BCG below this answer.

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