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THC, the main active substance of marijuana, activates the brain's endocannabinoid system, which is responsible for blocking seizures and exaggerated neuronal communication. So one's synaptic transmission goes down first after smoking marijuana. If one smokes it often, then the endocannabinoid receptors in her/his synapses start to disappear. It happens because the brain is getting used to the THC extent it gets regularly, so it do not need that much receptors to have the same balance as before the THC.

If one do not have the normal extent of endocannabinoid receptors it could lead to epilepsy and other pathological problems.

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16y ago

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