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All nucleotides have a 5-carbon sugar, a phosphate group, and a nitrogenous base. The bases are the differences. There are four bases in DNA: adenine, thymine, cytocine, and guanine. In RNA, the base Uracil replaces thymine. Adenine on one strand will always pair with a thymine on the other, and vice versa, while a cytosine on one strand will always pair with a guanine on the other strand. In RNA adenine will always pair with a uracil, and there is no thymine.

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