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DNA alterations could come in the form of Mutations which can be good or bad depending on many things. Some people would see anything that strays from the norm to be harmful in their species. One might be looked at as not good enough for their kind. I think mutation is also the most important form of genetic change. I think this because without some mutations (In our species) we would all be the same.

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Q: How might alterations in DNA structure be harmful to a species?
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