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A prokaryotic chromosome consists of a single molecule of DNA in the form of a closed loop. The chromosome is described as circular. A prokaryotic cell has only one chromosome. A eukaryotic chromosome is linear, not circular, in other words it has two ends, like a sausage. Each chromosome contains one molecule of DNA for the first half or so of interphase, then the DNA replicates, and the two DNA molecules remain together (as sister-chromatids) in the same chromosome for the rest of interphase. This does not happen in prokaryotic cells. Eukaryotic cells have more than onechromosome. A further difference: prokaryotic chromosomes consist only of a naked DNA molecule, but eukaryotic chromosomes also contain many molecules of proteins (mostly histones). The DNA is wound around these proteins.

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