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If heterozygous individuals are not favored, then the frequency of heterozygous individuals will decrease as the frequency of homozygous individuals increase.

This can be shown using the Hardy-Weinberg equation for allele frequencies in a population:

p2 + 2pq + q2 = 1 where q2 & p2 are the frequencies of the two different homozygous individuals (eg. aa and AA) and 2pq is heterzygous (eg. Aa). As the equation shows, if 2pq decreases, the other two variables must increase to compensate.

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Q: How would selection against heterozygous individuals over many generations affect the frequencies of homozygous individuals?
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