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To determine the commonly deleted region on chromosome
3 in carcinoma of the uterine cervix, these samples were also
examined for loss of heterozygosity at 5 other loci on chro
mosome 3: RAFl(3p24-25) (14); ERBAß(3p22-24.l ) (17);
DNF15S2 (3p21) (13); D3S3(3pl4) (13); and SST(3q28) (13).
Loss of heterozygosity at the RAF1 locus and the ERBAßlocus
was observed in one of 3 patients and 3 of 7 patients (Fig. 1, b
c), respectively, but no loss was observed at 2 other loci,
DNFI5S2 and SST, whereas duplication of one of two alÃeles
was observed in 2 of 6 patients at SST (Table 1). Analysis of
loss of heterozygosity at the ERBAßlocus was performed using
2 different DNA probes: a human ERBAßcomplementary DNA
clone, pheA4; and a genomic ERBAßDNA clone, pBH302 (15-
17). The pheA4 and pBH302 probes detect BamHl and Hindlll
RFLP, respectively, and loss of heterozygosity at this locus was
observed in none of 2 patients by using the pheA4 probe and
in 3 of 5 patients by the pBH302 probe (Table 1; Fig. lé).No
information was available on loss of heterozygosity at the D3S3
locus, because none of the 18 patients was heterozygous in
normal tissue at this locus. Therefore, the commonly deleted
chromosomal region in carcinoma of the uterine cervix is
probably a small part of the short arm of chromosome 3,
including the D3S2 locus. These results strongly suggest that
recessive genetic changes on chromosome 3p are involved in
the development of carcinoma of the uterine cervix.
What else can I help you with?
Which animal's genome has the highest percentage of similarity with the human genome?
The animal with the highest percentage of similarity to the human genome is the chimpanzee.
Which term describes the entire DNA of an organism?
Genome is the term used to describe the entire DNA of a organism. For instance, if referring to the entire DNA in a human, you would call it: 'the human genome."
What percent of the human genome is composed of these transposable sequences?
Approximately 45% of the human genome is made up of transposable elements. These sequences have the ability to move around the genome and can have significant impacts on gene regulation and genome evolution.
What is the name of the project that sequenced genes?
The Human Genome Project mapped and sequenced the entire human genome.
What percentage of the human genome is dedicated to protein coding?
Approximately 1-2 of the human genome is dedicated to protein coding.
What was the overall goal of the Human Genome Project?
To identify every human gene.<==== nova net answer.
What is human genome?
The human genome is the DNA or genetic blueprint for all people.
How many pairs of the human genome?
There are 23 pairs of chromosomes in the human genome.
What is the population of Human Genome Sciences?
Human Genome Sciences's population is 1,000.
When was Human Genome Sciences created?
Human Genome Sciences was created in 1992.
Which animal's genome has the highest percentage of similarity with the human genome?
The animal with the highest percentage of similarity to the human genome is the chimpanzee.
Which term describes the entire DNA of an organism?
Genome is the term used to describe the entire DNA of a organism. For instance, if referring to the entire DNA in a human, you would call it: 'the human genome."
What percent of the human genome is composed of these transposable sequences?
Approximately 45% of the human genome is made up of transposable elements. These sequences have the ability to move around the genome and can have significant impacts on gene regulation and genome evolution.
Which cancers does the human genome project help?
the human genome project helpes many different cancers
Why is a genome so important?
The human genome is all of the bodies DNA
Is the human genome different from the monkey genome?
They are about 93% similar in their genomes.
What is the name of the project that sequenced genes?
The Human Genome Project mapped and sequenced the entire human genome.
