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The vesicle pool in a cell functions in a cyclical manner there are very few 'one-way-trips' in a cell for a vesicle. Therefore there are not only vesicles that go from the ER to the Golgi, there are also vesicles that go from the Golgi to the ER.

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15y ago
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Q: If vesicles are almost constantly pinching off from the ER to carry proteins to the Golgi apparatus why does the ER not shrink and finally disappear?
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