Is Wagner's disease hereditary

Answer 1

Wagner disease / syndrome is a rare hereditary vitreo-retinal disease. It is one of the connective tissue disorders affecting the collagen. The main feature is an ‘empty’ vitreous that lacks the normal structure. Missing or weak vasculature in the peripheral retina makes the retina prone to tear or getting detached. Diminished visual acuity at night is also a problem as is early onset cataract (from the age of 30) and choroidal atrophy. A lot of people are moderate (> -2) to highly (> -6) myopic. Not everyone has this disease in the same degree: one quarter will have no or minor problems, half of the affected people have moderate problems and again one quarter has major problems (retinal detachment for instance). Wagner syndrome is a dominant autosomal disease. That means that 50% of your offspring will have the disease if you have Wagner. Wagner syndrome has been reported in families of various ethnic background including Caucasian, Japanese and Chinese. Recently the gene that is responsible for the disease is found. It is the Versican gene (CSPG2 = chondroitin sulfate proteoglycan 2) on the long arm (q) of the 5th chromosome (5q14.3). It causes a different expression of the proteins V0 and V1, as exon 8 is shorter or not ‘read’ at all. The disease is named after the Swiss ophthalmologist Hans Wagner, who described a family with this disorder in 1938. Since than no more than 50 families, some of them very large, or individual cases have been reported.

Answer 2

Yes, Wagner's disease is generally considered to be hereditary. It is caused by mutations in the CSPG2 gene, which is passed down in an autosomal dominant pattern. This means that a person only needs to inherit one copy of the mutated gene from one parent to develop the condition.

Answer 3

Yes, Wagner's disease is a genetic (hereditary) disease.