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Prokaryotes are a group of organisms that lack a membrane bound nucleus. Most prokaryotes are unicellular and are divided into two groups; bacteria and archaea. The word prokaryote comes from the Greek πρό- (pro-) "before" + καρυόν (karyon) " or nutkernel." The defining characteristic is the absence of a nucleus.

The genomes of prokaryotes are held within an irregular DNA/protein complex in the cytosol called the nucleoid, which lacks a nuclear envelope. Prokaryotes generally lack membrane-bound cell compartments: such as mitochondria and chloroplasts. Instead processes such as oxidative phosphorylation and photosynthesis take place across the prokaryotic plasma membrane. However, prokaryotes do possess some internal structures, such as cytoskeletons, and the bacterial order Planctomycetes have a membrane around their nucleoid and contain other membrane-bound cellular structures. Both eukaryotes and prokaryotes contain large RNA/protein structures called ribosomes, which produce protein. Prokaryotes are usually much smaller than eukaryotic cells.

Prokaryotes also differ from eukaryotes in that they contain only a single loop of stable chromosomal DNA stored in an area named the nucleoid, while eukaryote DNA is found on tightly bound and organized chromosomes. Although some eukaryotes have satellite DNA structures called plasmids, these are generally regarded as a prokaryote feature, and many important genes in prokaryotes are stored on plasmids. Prokaryotes have a larger surface area to volume ratio giving them a higher metabolic rate, a higher growth rate and consequently a shorter generation time compared to Eukaryotes.

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The nuclear envelope is found in eukaryotic cells, not in prokaryotic cells.


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Circular DNA is typically found in prokaryotic cells, such as bacteria, rather than in eukaryotic cells.


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