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Yes, oak tree [Quercus spp] sap is toxic. About the only life forms that can take in more than small amounts of tannins are squirrels [Sciuridae family] and mule deer [Odocoileus hemionus]. Specifically, prolonged intake of greater amounts of tannins may lead to anemia in humans. That's because tannins get in the way of the body's absorption of proper amounts of iron. Very few humans tolerate the bitter taste that tannins offer. Acorns that are sold for human consumption have had their tannins leached out.

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