Mode of action of ceftriaxone

Answer 1

The bactericidal activity of ceftriaxone results from inhibition of bacterial cell wall synthesis This antimicrobial agent Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs) which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Answer 2

Ceftriaxone is a third-generation cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins, disrupting the cross-linking of the bacterial cell wall, leading to cell lysis and death.