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This cycle occurs only in the presence of oxygen. It takes place in the mitochondria.

The oxidation of pyruvic acid into CO2 and water is called Krebs cycle:

Pyruvic acid +CoA --------> Acetyl CoA +CO2. This reaction is catalyzed by a set of enzymes called pyruvic acid dehydrogenase. In this reaction, 2 hydrogen atoms and one CO2 molecule are removed.

The 2 hydrogen atoms are accepted by NAD and NAD is converted into NADH.

Pyruvic acid and CoA are the reactants. The products are 2 H+ and CO2 and Acetyl CoA.

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