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The decline in the immune system with age is still an area of active investigation. A complete understanding of the molecular interactions and physiological mediators that being about this decline are not fully dissected as yet.

However, the general consensus is that there is a gradual decline the in the size of the thymus beginning at around age 20 and extending for the rest of the individuals life. This is one major reason to account for the decline in the immune system with age

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